Jacobson MH, Wu Y, Liu M, et al. - Researchers investigated how, in a cohort of children with chronic kidney disease (CKD), measures of kidney function, tubular injury, and oxidative stress could be impacted over time by serially evaluated exposure to bisphenol A (BPA) and phthalates. From 618 children and adolescents who were enrolled in an observational cohort study of pediatric CKD patients from the US and Canada (Chronic Kidney Disease in Children study), samples were obtained between 2005 and 2015. Experts analyzed levels of BPA, phthalic acid (PA), and phthalate metabolites as well as biomarkers of tubular injury and oxidative stress in urine samples obtained serially over an average of 3.0 years. Findings although demonstrated no link of BPA and phthalate metabolites with clinical renal endpoints such as estimated glomerular filtration rate or proteinuria, experts identified a consistent pattern of increased tubular injury and oxidative stress over time because of which renal function has been shown to be impacted in the long term. This raises concerns regarding the potential for clinically significant alterations in kidney function in correlation with exposure to common environmental toxicants at current levels.