Lee Y, Lai HTM, de Oliveira Otto MC, et al. - To examine the association with incident heart failure (HF) of long-term habitual levels and changes in levels of fatty acids (FAs) in the de novo lipogenesis (DNL) pathway, researchers undertook this study with 4,249 participants free of HF at baseline. They employed gas chromatography to determine plasma phospholipid FAs at baseline, 6 years, and 13 years. Via standardized methods, they measured risk factors for HF. Incident HF was centrally adjudicated utilizing medical records. Findings revealed a positive link of both habitual levels and changes in levels of 16:0 (palmitic acid) with incident HF in older adults. Experts also identified that alterations in 16:1n-9 (7-hexadecenoic acid) and 18:1n-7 (vaccenic acid) were also positively related to incident HF. These revelations imply that DNL or these DNL-associated FAs may have a potential role in the development of HF.