Yang Z, Cai Z, Cai Q, et al. - Researchers compared two treatment approaches for locoregionally advanced nasopharyngeal carcinoma (LA-NPC), in terms of efficacy and safety: induction chemotherapy (IC) followed by intensity-modulated radiotherapy (IMRT) alone vs concurrent CCRT (concurrent chemoradiotherapy). They randomly assigned patients with newly diagnosed stage III to IVB nasopharyngeal carcinoma (NPC) to receive IC plus IMRT (IC+RT arm), or concurrent chemotherapy plus IMRT (CCRT arm), employing a random number table. The same chemotherapy regimen was received by both treatment arms. The estimated 3-year progression-free survival (PFS), overall survival (OS), locoregional recurrence–free survival (LRRFS) and distant metastasis-free survival (DMFS) were 72.2%, 87.8%, 92.3%, and 82.7% in the IC+RT arm, vs 82.6%, 92.8%, 94.7%, and 88.2% in the CCRT arm. Findings showed that in terms of PFS, OS, LRRFS, and DMFS, similarly favorable treatment results were conferred by IC plus IMRT alone, vs CCRT, in patients with LA-NPC. There were fewer incidences of leukopenia and anemia in relation to IC plus IMRT when compared with CCRT.