Pearl TA, et al. - In view of the observed association of migraine with aura (MwA) with increased brain hyper-responsiveness to visual stimuli and increased visual network connectivity relative to migraine without aura (MwoA), researchers conducted this cross-sectional observational study examining if MwA vs MwoA is associated with greater symptoms of photophobia, phonophobia, and cutaneous allodynia. They analyzed 321 migraine patients (146 MwA; 175 MwoA) enrolled into the American Registry for Migraine Research. Observations revealed the association of MwA with higher photophobia symptom scores compared with MwoA. No association of aura with greater hyperacusis or interictal allodynia scores was evident. In complement with prior imaging and neurophysiologic studies, these findings support MwA to be linked with hyper-responsiveness of brain visual processing regions. Findings infer that MwA is linked particularly with visual hypersensitivity, as opposed to being linked with a general hypersensitivity to multiple types of sensory stimuli.