Tsolakis N, et al. - In patients with asthma (age 10-35 years) and IgE sensitization to cat, dog or horse extract (ImmunoCAP), researchers determined the prevalence and levels of IgE antibodies against different cat allergen components [Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins)]and their association with type-2 inflammation and total IgE. Using multiple linear regression and adjusting for possible confounders, independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analyzed. Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were found to be independently related to type-2 biomarkers and total IgE.