Ruggieri S, et al. – The relationships among respiratory symptoms and function, airway inflammation, allergen sensitization and indoor allergen concentration were examined. Despite differences in their atopic state, there appeared similar asthma phenotypes in children. Sensitizing allergens in the indoor environment seemed to increase airway inflammation worsening pulmonary function, in atopic children.

Methods

• Parental questionnaires were used to assess one hundred thirty two children aging 10-14 years and living in a Southern Mediterranean area.
• Along with the evaluation of home dust samples, spirometry, exhaled nitric oxide (FeNO), skin prick tests, total and specific serum IgE analyses were performed for the content in Der p 1 allergen.
• In view of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1 specific IgE level, three clusters were created.

Results

• Although its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE), Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25-75%).
• Similar to Cluster 2, Cluster 3 (Wh12m-/low IgE) showed the lowest FeNO values and pulmonary function.
• Both Der p 1 specific IgE and FeNO were positively correlated to dust Der p 1, within Cluster 1.