He YT, et al. - In this pilot study involving 20 people, researchers analyzed the sensitivity, specificity, and predictive value of oral mucosal brush biopsy (MBB) for the diagnosis of peanut allergy. For this investigation, people with no history of adverse reactions from eating peanuts had oral MBB and serum testing for peanut specific immunoglobulin E (sIgE). For oral MBB and sIgE testing, the optimal cutoff levels were 0.12 kU/L and 1.0 kU/L respectively. The sensitivity of oral MBB testing was 80% at 0.12 kU/L and the specificity was 85%, whereas the sensitivity of sIgE testing was 50% at 1.0 kU/L and the specificity was 100%. According to findings, oral MBB has shown high sensitivity and specificity for screening individuals with and without oral cavity clinical peanut reactivity and may be a potentially useful test method for future peanut allergy diagnosis.