Granström AL, et al. - In a population-based Swedish cohort, the risk for Hirschsprung disease (HSCR) in newborns after maternal intake of selective serotonin reuptake inhibitors (SSRI) was determined. The Swedish National Patient Register was used for the cases and the controls (five age- and sex-matched controls per case) were randomly selected among children without HSCR in the cohort. The Swedish Prescribed Drug Register provided data on maternal SSRI use during pregnancy. During the study period, the birth of 775,024 children was reported; of these, they included 150 cases of HSCR (112 males) and 750 controls (560 males). The analysis revealed no higher risk of HSCR owing to maternal intake of SSRI in this cohort.