Zhu J, et al. – The present inquiry was set to assess whether resting–state functional connectivity (rsFC) of the precuneus subregions is differentially affected in patients with major depressive disorder (MDD). The data presented in this work showed a selective functional dysconnectivity of the precuneus subregions in drug–naive MDD, characterized by the hyperconnnectivity between the dorsal–anterior subregion and regions involved in visual, executive control, sensorimotor and bottom–up attention functions.