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Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: A case-control study

BMC Neurology Apr 11, 2019

Rathnayake D, et al. - In this case-control study involving 72 Parkinson disease (PD) patients with assorted disease durations and 56 age- and gender-matched controls, researchers assessed the role of serum immune mediators IFNγ, TNFα, IL-10, and NOx in PD progression and preclinical diagnosis. There was a significant increase in serum IFNγ and IL-10 vs healthy controls in PD. The severity of the disease is impacted by both IFNγ and IL-10. Neurotoxicity mediated by TNFα, however, appears to happen in early PD. They suggested that a serum immune biomarker panel, IFNγ, IL-10 and TNFα, could be proposed as a potential state/diagnostic multi-biomarker panel of PD. Furthermore, IFNγ, IL-10 and NOx could be an ensemble of rate/prognostic biomarkers of PD progression.

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