Kosaki K, Takahashi K, Matsui M, et al. - This study’s findings demonstrate that age- or chronic kidney disease (CKD)-related decreases in the estimated nephron number (that is, the nephron index) may be accelerated by increased sedentary behavior.

• Researchers evaluated the daily time spent in sedentary behavior using a tri-axial accelerometer in 294 participants (182 non-CKD adults and 112 CKD patients).

• They found that advancing age and CKD were correlated with a progressive decrease in the nephron index value. It has been reported that CKD patients with more sedentary time also had a greater nephron index decrease in comparison with those with less sedentary time (P < 0.05).

• Multiple linear regression analysis demonstrated that there was an independent correlation between sedentary time and the nephron index after adjusting for age, gender, presence of CKD, overweight/obesity, medication use, and total wear time (β = −0.13, P = 0.035).