Pi X, et al. - In a population with low rates of maternal active smoking but high rates of secondhand smoke (SHS) exposure, researchers tested whether exposure to SHS during the periconceptional period among nonsmoking women was correlated with an increased risk for orofacial clefts (OFCs) in offspring. Participants in the study were 240 women with OFC-affected pregnancies and 1420 women who delivered healthy infants from a population-based case-control study in northern China during 2002 and 2016. Among nonsmoking mothers, maternal SHS exposure during the periconceptional period increases the risk for OFCs in offspring.