Erkamp JS, Voerman E, Steegers EAP, et al. - This study was sought to investigate whether single or combined second and third trimester ultrasound in addition to maternal characteristics at the start of pregnancy are optimal to detect fetuses at risk for preterm birth, gestational age (SGA)  and large size for gestational age (LGA). A prospective population-based cohort was included a total of 7,677 pregnant women to assess second and third trimester estimated fetal weight, and uterine artery pulsatility and umbilical artery resistance indices as placenta flow measures. They tested screening performance via receiver operating characteristic curves and area under the curve along with sensitivity at different false-positive rates. The study demonstrates that combining single third trimester fetal and placental ultrasound results with maternal characteristics has the best screening performance for risks of preterm birth, SGA and LGA. Results reveal that third trimester screening may double the prognostication of fetuses at risk of common adverse birth outcomes, as matched with second trimester screening,