Wertaschnigg D, Rolnik DL, Nie G, et al. - Researchers conducted a case–control study drawn from a prospective observational study on adverse pregnancy outcomes in women attending for their routine second‐ and third‐trimester hospital visits, with the aim to compare asymptomatic women who subsequently developed preterm or term PE and healthy controls regarding serum levels of growth‐differentiation factor‐15 (GDF‐15) at three different gestational ages. Findings revealed an increase in the values of GDF‐15 with gestational age. They indicated no predictive value of serum GDF‐15 levels at 19–24 or 35–37 weeks of gestation for preterm or term PE. Higher GDF‐15 levels were reported at 30–34 weeks in women who subsequently develop preterm PE; however, this difference is small and GDF‐15 does not appear valuable in clinical practice when used in isolation.