Pazos M, Biarnés M, Blasco-Alberto A, et al. - In this prospective study, researchers sought to identify objective glaucoma-related structural features based on peripapillary (p) and macular (m) spectral domain optical coherence tomography (SD-OCT) parameters and evaluate their discriminative ability between healthy and glaucoma patients. Two hundred and sixty eyes (91 controls and 169 glaucoma) have been involved. All participants had the posterior pole and the peripapillary retinal nerve fibre layer (pRNFL) protocols of the Spectralis SD-OCT after a complete examination. In order to summarize structural data in healthy and glaucomatous eyes, principal component analysis identified a diffuse representation of the papillary and macular SD-OCT parameters as the most important principal component (PC). PCs and pRNFL parameters exhibited the greatest ability to discriminate between healthy cases and glaucoma.