Han R, Chen G, Li M, et al. - As there are only a few studies investigating genes linked with lymph node metastasis in esophagogastric junction adenocarcinoma (EJA), researchers herein screened lymph node metastasis-associated genes and examined their expression status and prognostic significance in EJA. They used targeted next-generation sequencing (tNGS) to determine the differential frequency of mutations between carcinoma and para-carcinoma tissues from 199 cases with EJA. Findings suggest that in patients with EJA, a high CDK6 and LRP1B expression status promotes and inhibits lymph node metastasis, respectively, indicating a significant potential predictive value of both CDK6 and LRP1B for lymph node metastasis and prognosis in EJA.