Wedrychowicz A, et al. - In children and adolescents with type 1 diabetes mellitus (T1D), researchers evaluated the sclerostin and its association between other bone and fat-related factors as well as glucose metabolism vs their healthy peers. In children and adolescents with T1D, a possible relationship between sclerostin and glucose metabolism was suggested. If an increase in sclerostin levels could present as a potential cause of the reduction of bone formation in T1D, it would be worth to investigate. The participation of sclerostin in metabolic regulation in T1D was seen to be possibly modulated with both bone-derived osteocalcin (OC) as well as fat-derived leptin.