Mariampillai JE, et al. - In 1392 men who were healthy when evaluated by two bicycle exercise tests 7 years apart, researchers assessed long-term risk of coronary heart disease (CHD) in relation to exercise SBP at a moderate workload. Based on the highest SBP during the initial 6 min of the exercise test on a moderate workload of 100 W (SBP100W) at 7 years and followed for up to 28 years, participants were categorized into quartiles, Q1–Q4. The first occurrence of angina pectoris, nonfatal myocardial infarction or CHD mortality was assessed using adjusted Cox regression. In association with exercise SBP above 180 mmHg at moderate workload, an increased long-term risk of CHD was observed among healthy middle-aged men. Compared with Q1 (≤160 mmHg, lowest SBP100 W), Q3 (SBP100 W above 180 mmHg) and Q4 (SBP100 W above 200 mmHg) demonstrated an increased risk of CHD in the multivariate analysis adjusting for classical coronary risk factors, including SBP at rest.