Grandi G, Sammarini M, Cortesi L, et al. - Prophylactic risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA carriers. Researchers here prospectively examined women undergoing RRSO for the level of satisfaction, also in relation to some specific characteristics at RRSO. A prospective cohort study was performed recruiting all BRCA1/2 confirmed mutation carriers who decided to undergo RRSO between 2016 and 2019 in the Modena Family Cancer Clinic of the University Hospital of Modena (Italy). They included 55 women (29 BRCA1 and 26 BRCA2) (mean age: 50.4 ± 7.7 years [range 35-79]) with a mean follow-up period of 660.9 days (1.8 years) after RRSO. Findings revealed a very high satisfaction with RRSO and participants’ characteristics at surgery had little impact on satisfaction. High satisfaction was recorded among women at high risk for ovarian cancer with respect to their choice of risk-reduction strategy.