Trieu MC, Bansal A, Madsen A, et al. - Due to overburdened healthcare systems, healthcare workers (HCW) in many countries experienced infection during the coronavirus disease 2019 (COVID-19) pandemic. However, it remains unclear if infected HCW acquire protective immunity against SARS-CoV-2. Hence, Norwegian HCW were examined in a prospective cohort study for SARS-CoV-2-specific antibody responses. Researchers performed enrollment of a total of 607 HCW pre- and post-the first COVID-19-pandemic wave. Per findings, HCW with COVID-19-patient exposure showed an increase in spike-specific IgG, IgM, and IgA antibodies after the first pandemic wave. A low number of SARS-CoV-2-seropositive HCW was identified in a low prevalence setting, however, there was a higher proportion of seropositivity than RT-PCR positivity, emphasizing the relevance of antibody testing.