Maheshwari J, Kolaitis NA, Anderson MR, et al. - Given a link between frailty and mortality in lung transplantation (LT), and given that sarcopenia is regarded as a cardinal component of frailty, so, researchers assessed this link in lung disease. They tested 3 sarcopenia definitions, including European Working Group on Sarcopenia in Older People (EWGSOP), Foundation for the National Institutes of Health (FNIH) Sarcopenia Project, and the lowest quartile of gender-specific appendicular skeletal muscle (ASM) mass index, in a multicenter prospective cohort including 367 LT candidates. The prevalence of sarcopenia was estimated to be 13% and 12% by EWGSOP and by FNIH, respectively. For Short Physical Performance Battery (SPPB) and for Fried Frailty Phenotype (FFP), the estimated frailty prevalence was 17% and 30%, respectively. Sarcopenia was found to be related to a higher risk of SPPB and FFP frailty by EWGSOP, but not by FNIH. Overall, in LT candidates, sarcopenia was shown to be related to frailty by EWGSOP and ASM mass index lowest quartile definitions.