Elbers JBW, et al. - Experts sought to ascertain the difference in prognosis per tumor subsite, corrected for disease stage, and the differences in prognosis after salvage surgery for local, regional, and locoregional recurrences. More favorable loco(regional) control but not favorable disease-free survival (DFS) than pharyngeal carcinoma was resulted by salvage surgery for larynx carcinoma, regardless of disease stage and other prognostic factors. After correction for confounders, the observed difference in DFS between salvage surgery for local and regional recurrences was not significant. Nonetheless, for locoregional disease survival following salvage surgery is significantly worse. For this subgroup, T status and comorbidity for clinical decision making was proposed to be considered, as high pT stage and American Society of Anesthesiologists (ASA) score are independent predictors for worse DFS.