Rivière E, Pascaud J, Tchitchek N, et al. - In this research, the interactions between salivary gland epithelial cells (SGECs) from patients with primary Sjögren's syndrome (pSS) or controls and B lymphocytes were explored. Researchers conducted gene expression analysis of SGECs and B lymphocytes from pSS and controls isolated from salivary gland biopsies and blood by RNA-seq. They also conducted transwell and inhibition experiments. The evidence suggested that SGECs from individuals with pSS had better ability than those from controls to induce survival and activation of B lymphocytes. Whereas leflunomide, Bruton's tyrosine kinase or PI3K inhibitors partially decreased B-lymphocyte viability in this model, targeting a single cytokine did not inhibit this impact. In pSS, this gives indications for future therapeutic options.