Sacdalan C, et al. – This study was performed with the aim to describe baseline and longitudinal hemoglobin changes among participants with acute HIV infection (AHI). Observations suggested rarity of anemia after frequent phlebotomy in research participants with AHI, before and after antiretroviral therapy. As no substantial clinical risk was evident with the blood volume drawn from this study, increasing the volume of blood drawn for research purposes in acute HIV–infected research participants could be considered for future studies.