Glass HC, Soul JS, Chang T, et al. - In this comparative effectiveness study involving 303 children with neonatal seizures, experts aspired to explore whether antiseizure medication (ASM) discontinuation after resolution of acute symptomatic neonatal seizures and before hospital discharge is correlated with functional neurodevelopment or risk of epilepsy at age 24 months. The majority of neonates [64%] had ASM maintained at the time of hospital discharge. There was no difference in functional neurodevelopment or epilepsy at 24 months among children whose ASM was discontinued vs maintained at hospital discharge after resolution of acute symptomatic neonatal seizures in this comparative effectiveness study. Such findings support discontinuing ASM prior to hospital discharge for the vast majority of infants with acute symptomatic neonatal seizures.