Secemsky EA, Shen C, Schermerhorn M, et al. - The non-inferiority of peripheral drug-coated devices (DCDs) for mortality to non–drug-coated devices (NDCDs) was evident in a cohort analysis of 168,553 Medicare fee-for-service beneficiaries who had femoropopliteal artery revascularization.

• This is an initial report from the SAFE-PAD cohort study (a retrospective cohort study).

• A median follow-up of 2.72 years (interquartile range, 0.87-3.77; longest, 5.16 years) was performed.

• At 5 years, the weighted cumulative incidence of mortality was 53.8% and 55.1% with DCDs and with NDCDs, respectively.

• No harm related to DCDs was noted among subgroups.

• The observed non-inferiority of DCDs for mortality remained robust in sensitivity analyses and was consistent across prespecified subgroups.