Crowell TA, et al. - Researchers examined if adults who initiated antiretroviral therapy (ART) during acute HIV infection can achieve sustained viral control once off ART with VRC01. In this randomized, double-blind, placebo-controlled trial performed at the Thai Red Cross AIDS Research Centre in Bangkok, Thailand, individuals who initiated ART during acute HIV infection found VRC01 monotherapy to be well tolerated. However, the therapy led to no significant increase in the number of participants with viral suppression 24 weeks after ART interruption.