Khalili M, Amiri R, Iranmanesh B, et al. - Various types of mesotherapy for treating melasma were reviewed, and findings indicate mesotherapy as a good alternative or adjunctive choice for certain patient groups.

• Google Scholar, Medline, and PubMed were explored, and 33 articles assessing efficacy of mesotherapy in melasma were selected (28 articles about tranexamic acid, 4 articles about vitamin C, 2 articles about glutathione, and 2 articles about triamcinolone).

• In the following patient groups, the utility of mesotherapy as a good alternative or adjunctive option is evident: patients who are refractory to first-line therapy, those with low compliance with everyday use of topical therapy, patients with contraindication to oral tranexamic acid therapy, or who desire short downtime and fast recovery period.