Nakou V, et al. – This study aimed to explain the dose range and safety profile of clonidine treatment in a case–series of children with severe acute exacerbation of dystonia in a tertiary hospital setting. In the acute management of severe exacerbations of dystonia, high dose clonidine administered via different routes could be used. In this cohort, its use was not correlated with significant cardio–respiratory depression even at doses as high as 9 mcg/kg/hr.