Forester BP, et al. - The safety and effectiveness of 6 months of treatment with lurasidone in older adults with a diagnosis of bipolar I depression were assessed. Outcomes of these post-hoc analyses found that in older adults, up to 7.5 months of lurasidone treatment for bipolar depression was correlated with minimal effects on weight and metabolic parameters, with low rates of switching to hypomania or mania, and was well-tolerated. In this age group, the antidepressant effectiveness of lurasidone was maintained over the 6-month treatment period.