Summary - S100A4 controls stemness and EMT in glioblastomas, suggesting that S100A4 is a candidate therapeutic target.

Methods
Glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT) were studied.

Results
Selective ablation of S100A4-expressing cells blocked tumor growth in vitro and in vivo.
S100A4 was shown to regulate GSC self-renewal in mouse and patient-derived glioma tumorspheres. 
S100A4 is an upstream regulator of the master EMT regulators (SNAIL2 and ZEB) with other mesenchymal transition regulators in glioblastoma.