Wang L, et al. - Authors sought to identify the biomarkers of articular and ocular disease activity in patients with Blau syndrome (BS). The clinical parameters were active joint counts, standardization uveitis nomenclature for anterior uveitis cells and vitreous haze by Nussenblatt scale. Experts noted that for S100A12 and S100A8/9 positive correlations between active joint counts and S100 levels were significant. CRP levels did not correlate with the active joint count. A significant association of S100 proteins with active arthritis was seen. They did not note any association of active uveitis with increased S100 levels. Results suggested that in BS, S100 proteins were biomarkers of articular disease activity. As secreted neutrophil and macrophage products, the burden of granulomatous tissue in BS could be reflected by S100 proteins.