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S-glutathionylation of the Na+-K+ pump: A novel redox mechanism in preeclampsia

Journal of Clinical Endocrinology and Metabolism Jan 07, 2021

Liu CC, Zhang Y, Makris A, et al. - Experts aspired to explore whether β 1 subunit (GSS-β 1) protein glutathionylation of the Na+-K + pump occurs in preeclampsia. Between women with healthy pregnancies and women with preeclampsia, the GSS-β1 of the Na+-K+ pump and its subunit expression in human placentas were compared. In the placentas of women with preeclampsia vs those with normotensive pregnancies, the protein expression of the β 1 subunit was unchanged. New insights into the mechanism of Na+-K+ pump dysfunction in preeclampsia are provided by the high level of β 1 pump subunit glutathionylation.

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