Liu CC, Zhang Y, Makris A, et al. - Experts aspired to explore whether β ₁ subunit (GSS-β ₁) protein glutathionylation of the Na⁺-K ⁺ pump occurs in preeclampsia. Between women with healthy pregnancies and women with preeclampsia, the GSS-β₁ of the Na⁺-K⁺ pump and its subunit expression in human placentas were compared. In the placentas of women with preeclampsia vs those with normotensive pregnancies, the protein expression of the β ₁ subunit was unchanged. New insights into the mechanism of Na⁺-K⁺ pump dysfunction in preeclampsia are provided by the high level of β ₁ pump subunit glutathionylation.