Ruthenium-106 vs iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm
British Journal of Ophthalmology Mar 29, 2019
Fili M, et al. - Investigators studied 317 participants to assess the ocular as well as the patient survival in thicker tumors treated with γ-emitting iodine-125 (125I) and β-emitting ruthenium-106 (106Ru). A significantly higher rate of repeated brachytherapy was reported among those treated with 106Ru (8%) when compared with 125I. They observed similar Kaplan-Meier disease-specific and relative 10-year survival in matched groups of 5.5–7.4 mm (relative survival 106Ru 59%, 125I 56%) and ≥7.5 mm thick tumors (relative survival 106Ru 46%, 125I 44%). Overall, they concluded rates of enucleation or patient survival were not significantly different.
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