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Routine third‐trimester ultrasound for the detection of small‐for‐gestational age in low‐risk pregnancies (ROTTUS study): Randomized controlled trial

Ultrasound in Obstetrics & Gynecology Jun 08, 2021

Wanyonyi SZ, Orwa J, Ozelle H, et al. - In this open-label randomized controlled trial, compared were the proportion of small-for-gestational-age (SGA) infants detected using routine third-trimester ultrasound vs those detected by selective ultrasound based on serial symphysis–fundus height (SFH) measurements (standard care) in low-risk pregnancy. In this trial, 508 low-risk pregnant women were randomly allocated (ratio of 1:1) to routine ultrasound for fetal growth assessment between 36 + 0 and 37 + 6 weeks' gestation (intervention group) or to standard care, which involved a selective growth scan on clinical suspicion of fetal growth abnormality based on serial SFH measurements (control group). Outcomes suggest superiority of routine ultrasound performed between 36 + 0 and 37 + 6 weeks to selective ultrasound based on serial SFH measurements for the detection of true SGA in low-risk pregnancy, with high specificity.

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