Ashir A, Ma Y, Jerban S, et al. - To apply quantitative MRI to evaluate the bilateral RCTs in the shoulders of both patients with unilateral symptomatic tendinopathy and control subjects. Researchers assumed that quantitative MRI measures would differ between symptomatic patients and controls. Researchers carried out a prospective imaging study including 48 shoulders from 24 individuals (mean age, 32.8 years), involving 14 individuals with unilateral symptomatic tendinopathy and 10 asymptomatic controls. They assessed macromolecular fraction (MMF) and T2 relaxation measured in four regions of the superior RCT, including all-segments, and lateral-third, bursal-sided, and articular-sided segments. The Western Ontario Rotator Cuff (WORC) index and visual analog scale were evaluated. Compared with control RCTs, symptomatic RCTs revealed significantly lower MMF values and higher T2 values. The contralateral shoulder can illustrate asymptomatic tendinopathy, which can be quantified using MMF or T2 in individuals with unilateral symptomatic tendinopathy.