Ashir A, Ma R, Jerban S, et al. - Researchers intended to assess the bilateral randomized controlled trials (RCTs) in shoulders of both patients with unilateral symptomatic tendinopathy and control subjects using quantitative MRI . They assumed that quantitative MRI measures would differ between symptomatic individuals and controls. A prospective imaging study was conducted to enroll 48 shoulders from 24 individuals (mean age, 32.8 years), involving 14 individuals with unilateral symptomatic tendinopathy and 10 asymptomatic controls. They assessed macromolecular fraction (MMF) and T₂ relaxation in four regions of the superior RCT, including all‐segments, and lateral‐third, bursal‐sided, and articular‐sided segments. The Western Ontario Rotator Cuff index and visual analog scale were measured. Compared with control RCTs, symptomatic RCTs displayed significantly lower MMF values and higher T2 values. The contralateral shoulder can indicate asymptomatic tendinopathy, which can be quantified using MMF or ₂, in individuals with unilateral symptomatic tendinopathy.