Alipoor E, et al. - Researchers undertook this preliminary study to determine adipolin (an adipocytokine with major beneficial impacts on insulin sensitivity) levels as well as its link with insulin resistance (IR) and other cardiovascular risk factors in 24 obese patients having type 2 diabetes (DM) and 30 with hemodialysis (14 with diabetes and hemodialysis (HD/DM) and 16 with hemodialysis (HD/non-DM)). Compared with HD/DM and HD/Non-DM groups, the DM group exhibited higher serum adipolin. An inverse link of adipolin with insulin level and homeostatic model assessment of insulin resistance was identified. DM vs HD/DM and HD/Non-DM groups demonstrated higher LDL level. A direct correlation of adipolin with cholesterol and LDL levels was observed. Experts concluded that a compensatory rise in adipolin generation or secretion to modulate IR might be suggested by the observed higher adipolin level in DM group. It might also be attributable to medications and inflammation.