Prasad N, Johng SY, Powell D, et al. - In the present study, the researchers sought to explore caregiver satisfaction with treatments for pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) and how symptom frequency changes over time. From 2015 to 2018, a list of PANDAS patients seen at the Georgetown Pediatric Otolaryngology clinic was compiled. Patients were placed in groups on the basis of reported treatments: tonsillectomy and adenoidectomy (T&A, n = 28), T&A and intravenous immunoglobulin (IVIG, n = 22), or nonsurgical treatment(s) (n = 10). Study participants were treated with antibiotics (n = 60, 100%), T&A (83.3%), IVIG (40%), rituximab (15%), steroids (20%), and/or plasma exchange (10%). Regardless of treatment, caregivers reported a decline in symptom frequency over time and no changes in satisfaction. Findings suggested that T&A was the most preferred and most effective treatment for surgical patients with symptoms. T&A in conjunction with antibiotics should be viewed as an early intervention for PANDAS, considering the challenges of immunologic therapies.