Mannu GS, et al. - Researchers investigated the efficacy of tamoxifen therapy in resolving idiopathic gynecomastia, a benign breast disorder characterized by overdevelopment of male breast tissue. At their breast clinic, they performed a prospective cohort study of male patients presenting with primary gynecomastia who also had treatment with a trial of tamoxifen 10 mg daily therapy, over a 10-year period from October 2004 to October 2015. This is the largest study that investigated the role of tamoxifen in idiopathic gynecomastia. Findings revealed successful resolution of symptoms in approximately nine out of 10 men treated with tamoxifen therapy. After a careful discussion of risks and benefits, eligible men with idiopathic gynecomastia could be treated with this therapy.