Raggio BS, et al. - A sum of 25,328 cases (36-82 years of age) with head and neck cancer were estimated to analyze the efficacy of steroids in the prevention of osteoradionecrosis of the head and neck using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. With limited retrospective data, researchers observed a relationship between the use of pretreatment steroids and significantly lower risk for osteoradionecrosis, with a hazard ratio of 0.74 and a relative risk of 0.04.