Shamji MH, et al. - Authors gauged the mechanisms underlying the induction and maintenance of immunological tolerance induced by IL-35 and iT_R35 cells. Findings suggested that potential novel immune-regulators induced by sublingual immunotherapy (SLIT) were IL-35 and iT_R35 cells. There was a possibility of the restoration of protective iT_R35 cells to underscore the clinical relevance of SLIT. Th2 cell proliferation and cytokine production were suppressed by iT_R35 cells.