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Role of doppler ultrasound at time of diagnosis of late‐onset fetal growth restriction in predicting adverse perinatal outcome: Prospective cohort study

Ultrasound in Obstetrics & Gynecology May 13, 2020

Rizzo G, Mappa I, Bitsadze V, et al. - Researchers aimed at ascertaining the strength of correlation between fetoplacental Doppler indices at the time of diagnosis of late‐onset fetal growth restriction (FGR) and adverse perinatal outcome. In addition, they investigated their predictive accuracy. In this prospective study of 243 consecutive singleton pregnancies complicated by late‐onset FGR, they defined late‐onset FGR as estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd centile, or EFW or AC < 10th centile and umbilical artery (UA) pulsatility index (PI) > 95th centile or cerebroplacental ratio (CPR) < 5th centile, diagnosed after 32 weeks. Findings suggest an independent association of CPR and uterine artery PI assessed at the time of diagnosis with composite adverse perinatal outcome in pregnancies complicated by late‐onset FGR, however, their diagnostic yield for composite adverse perinatal outcome is low. For prediction of composite adverse perinatal outcome, they identified better accuracy of umbilical vein blood flow normalized for fetal abdominal circumference, although its usefulness in clinical practice as a standalone predictor of adverse pregnancy outcome needs further investigation.

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