Gritter M, et al. – In this brief review, researchers intended to gain insight into the current knowledge base of the influences of dietary K⁺ on blood pressure, cardiovascular health, and renal health. They also attempted to offer a mechanistic framework for these effects. A beneficial effect of K⁺ has been suggested by an overwhelming evidence; however, some studies have reported adverse outcomes. The possibility that a diet high in K⁺ is renoprotective represents an opportunity for patients with chronic kidney disease (CKD). Patiromer and sodium zirconium cyclosilicate are being recognized as novel oral treatments that permit continuation of renin-angiotensin inhibitors—and the related cardiorenal benefits—while preventing hyperkalemia. The potentially beneficial effects of dietary K⁺ in patients with CKD could be limited by attenuating intestinal K⁺ absorption through these binders. After all, a high K⁺ diet has been recognized as a powerful nonpharmacological approach to lessen the burden of cardiovascular disease.