Chen MT, et al. – This randomized controlled trial was performed to examine the efficacy of a selective cyclooxygenase–2 (COX) inhibitor (parecoxib) on postoperative pain management for open hepatic hemangioma resection. After open hepatic surgery, a selective COX–2 inhibitor relieved postoperative pain. 48 hours after surgery, parecoxib reduced systemic erythrocyte sedimentation rate (ESR), interleukin (IL)–6, IL–4, and transforming growth factor (TGF)–beta concentrations, showing that both the COX–2 pathway and an immune cell balance effect was involved in surgery–induced inflammation.