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RNA sequencing and pathway analysis identify tumor necrosis factor alpha driven small proline-rich protein dysregulation in chronic rhinosinusitis

The American Journal of Rhinology & Allergy Sep 16, 2017

Ramakrishnan VR, et al. - The researchers examined the expression of small proline-rich proteins (SPRR) in chronic rhinosinusitis (CRS). They discovered that the expression of SPRR1 and of SPRR2A was increased in mucosal samples of patients with CRS. This appeared as a downstream result of tumor necrosis factor (TNF) alpha modulation, which possibly resulted in epithelial barrier dysfunction.
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