Wu YM, Guo Y, Yu H, et al. - It was shown that RNA editing affects cis-regulatory elements and predicts adverse cancer survival.

• Researchers distinguished 402 gene-proximal RNA-editing sites that generally predict adverse cancer survival.

• With a hazard ratio of 2.13 and an adjusted p-value of 4.07 × 10−7, an RNA-editing site residing in ZNF264 demonstrates poor survival of uterine corpus endometrial carcinoma.

• The study demonstrated that some of these prognostic RNA-editing sites mediate the binding of RNA binding proteins and microRNAs, therefore propagating their impacts to extensive regulatory targets.