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Risks associated with continuation of potentially inappropriate antihypertensive medications in older adults receiving hemodialysis

BMC Nephrology Jun 24, 2021

Hall RK, Morton S, Wilson J, et al. - Researchers used United States Renal Data System data to analyze antihypertensive potentially inappropriate medication (PIM) prescribing patterns prior to as well as post- dialysis initiation, and to determine the potential risk of adverse results when these medications were continued following dialysis initiation. Participants were older adults aged ≥66 years starting in-center hemodialysis in the US between 2013 and 2014. Patients with an antihypertensive PIM prescription at hemodialysis commencement and who survived for 120 days were grouped as ‘continuers’ or ‘discontinuers’ depending on presence or absence of a refill within the 120 days post-initiation. Findings revealed that nearly one in five older adults was observed to have an antihypertensive PIM at dialysis commencement. An antihypertensive PIM continuation was not related to elevated risk of all-cause hospitalization or mortality in participants who survived ≥120 days.

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