Sherbash M, et al. - Researchers analyzed five randomized controlled trials (RCTs) with 85,095 children, to compare wheezing as well as asthma exacerbations among children taking paracetamol vs ibuprofen. The relevant RCTs were identified via a comprehensive search in five databases. Experts used the Peto’s odds ratio to estimate the pooled effect size. As far as the odds of developing asthma or presenting an exacerbation of asthma among children who took paracetamol vs ibuprofen was concerned, no difference was indicated by the pooled estimate. Despite the findings being suggestive of similar tolerance and safety profiles of ibuprofen and paracetamol in terms of incidence of asthma exacerbations in children, high quality trials with clear definition of asthma results following the receipt of ibuprofen or paracetamol at varying doses with longer follow-up are justified for any conclusive finding.