Bertoli HK, et al. - Researchers estimated the risk of vulvar, vaginal and anal intraepithelial neoplasia grade 2/3 or cancer (VIN2+, VaIN2+, AIN2+) by cervical high-risk human papillomavirus (hrHPV) status in this prospective cohort analysis. From a total of 40,399 women who were screened against cervical cancer in Copenhagen, Denmark, during 2002–2005, experts obtained liquid-based cervical cytology samples. Analysis of these samples was performed using Hybrid Capture 2 (HC2) to determine hrHPV, and samples were genotyped using INNO-LiPA. Increased hazard of VIN2+, VaIN2+ and AIN2+ was observed in women with cervical HPV16 infection vs HC2 negative women. Increased hazard of VaIN2+, as well as a borderline statistically significantly raised risk of AIN2+, was noted in women with other hrHPV types than HPV16 vs HC2 negative women. In women with cervical HPV16, the 10-year cumulative incidence of VIN2+ was 0.3%, of VaIN2+ was 0.2%, and that of AIN2+ was 0.1%. Overall, findings revealed a link of cervical HPV16 infection with increased risk of VIN2+, VaIN2+ and AIN2+.